Why pyruvate not converted directly into phosphoenolpyruvate?
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Conversion of pyruvate to phosphoenolpyruvate occurs by a combination of two
reactions, and requires hydrolysis of two ATP to ADP. In the first reaction, pyruvate is
converted to oxaloacetate by pyruvate carboxlyase, which uses biotin as a cofactor.
This reaction takes place in the mitochondrial matrix and is also used to generate
oxaloacetate as an intermediate in the TCA cycle, as will be discussed later. This reaction
depends on an ATP-dependent carboxylation of biotin.
Conversion of pyruvate to phosphoenolpyruvate occurs by a combination of two
reactions, and requires hydrolysis of two ATP to ADP. In the first reaction, pyruvate is
converted to oxaloacetate by pyruvate carboxlyase, which uses biotin as a cofactor.
This reaction takes place in the mitochondrial matrix and is also used to generate
oxaloacetate as an intermediate in the TCA cycle, as will be discussed later. This reaction
depends on an ATP-dependent carboxylation of biotin.
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