Question

Why reaction with acid chloride is carried in the presence of pyridine?

Answer 1

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HERE IS YOUR ANSWER:




Pyridine is a reasonable nucleophile for carbonyl groups and is often used as a catalyst in acylation reactions. The nitrogen atom in pyridine is nucleophilic because the lone pair of electrons on nitrogen cannot be delocalised around the ring.

Esters are often made in pyridine solution from alcohols and acid chlorides.






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