Question

why sulphonamides is not active in the presence of pus?​

Answer 1

Answer:

Because the activity is by competitive substitution, the sulfonamide tissue concentration must be kept high enough to prevent bacterial access to PABA. Therefore the sulfonamides are ineffective in pus and necrotic tissue, which provide additional sources of PABA to the bacteria.

Answer 2

Because the activity is by competitive substitution, the sulfonamide tissue concentration must be kept high enough to prevent bacterial access to PABA. Therefore the sulfonamides are ineffective in pus and necrotic tissue, which provide additional sources of PABA to the bacteria.