Why threonine does not undergo transamination?
Answers
Required Answer
Because for two substances to undergo a transamination reaction one must be an alpha amino acid, which Lysine is (it also contains a free amino group in its side chain).
Proline is not an alpha keto acid, it is an amino acid which comprises its alpha amino group in a cyclic form (it is a pyrrolidine ring).
Additional Information
- What is Threonine?
Threonine is an amino acid that is used in the biosynthesis of proteins. It contains an α-amino group, a carboxyl group, and a side chain containing a hydroxyl group, making it a polar, uncharged amino acid.
It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the Diet.
- Function of Threonine
- The amino acid threonine is an essential amino acid, vital in protein synthesis.
- Threonine is obtained through things we eat, like meat, milk and beans.
- The side chain structure of threonine is C2H5O.
- This amino acid is vital in the folding and function of proteins.
- What is Transamination?
Transamination, a chemical reaction that transfers an amino group to a ketoacid to form new amino acids. This pathway is responsible for the deamination of most amino acids. This is one of the major degradation pathways which convert essential amino acids to non-essential amino acids.
- Importance of Transamination
Transamination is important for redistribution of amino groups & production of non-essential amino acids.
It diverts excess amino acids towards the energy generation.
Amino acids undergo transamination to finally concentrate nitrogen in glutamate.
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