why will the ratio of free PSA to bound PSA decrease in prostate cancer
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Most PSA in the blood is bound to other proteins. Normally, more than 23% of serumPSA is in its free form (free PSA). Benignprostate tumors (prostatic hyperplasia, BPH) may be associated with elevated PSA, especially free PSA. With prostate carcinoma, however, the proportion of free PSAdecreases.
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