Question

with suitable schematic diagram explain mitochondrial dysfunction is related to bipolar disorder.
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Answer 1

Answer:

bipolar

Explanation:

Bipolar disorder is one of two major psychotic disorders together with schizophrenia and causes severe psychosocial disturbance. Lack of adequate animal models hampers development of new mood stabilizers. We proposed a mitochondrial dysfunction hypothesis and have been studying the neurobiology of bipolar disorder based on this hypothesis. We showed that deletions of mitochondrial DNA (ΔmtDNA) play a pathophysiological role at least in some patients with bipolar disorder possibly by affecting intracellular calcium regulation. Mutant polymerase γ transgenic mice that accumulate ΔmtDNA in the brain showed recurrent spontaneous depression-like episodes which were prevented by a serotonin-selective reuptake inhibitor and worsened by lithium withdrawal. The animal model would be useful to develop new mood stabilizers.

Answer 2

Explanation:

Bipolar disorder remains a prevalent and serious psychiatric disorder.1 Although a number of pharmacological treatments for bipolar disorder exist, including mood stabilizers such as lithium and valproic acid, none have emerged as singularly effective against all aspects of the illness. Furthermore, the large range of available remedies implies a poor understanding of the underlying pathophysiology of bipolar disorder.