Question

Write a note on Chloride channels and their modulators.

Answer 1

$\underline\bold{\huge{Answer !!}}$

The prime roles of mutations in

the genes, encoding chloride ion channels, in various human

diseases of muscle, kidney, bone

and brain, such as congenital

myotonia, myotonic dystrophy,

cystic fibrosis, osteopetrosis,

epilepsy, glioma, etc., have been

well established. Chloride ion

channels are also responsible for

glioma progression in brain and

malaria parasite in red blood cells.

The present article thus emphasises

on the various diseases associated

with chloride channel regulation and their modulators.