Write a note on poisoning of carbon monoxide.
Answers
Answer:
Carbon monoxide poisoning typically occurs from breathing in carbon monoxide (CO) at excessive levels.
Symptoms are often described as "flu-like" and commonly include headache, dizziness, weakness, vomiting, chest pain, and confusion. Large exposures can result in loss of consciousness, arrhythmias, seizures, or death. The classically described "cherry red skin" rarely occurs. Long term complications may include feeling tired, trouble with memory, and movement problems. In those exposed to smoke, cyanide toxicity should also be considered.
Carbon monoxide poisoning can occur accidentally, as an attempt to end one's own life, or as an attempt to end another's life. CO is a colorless and odorless gas which is initially non-irritating. It is produced during incomplete burning of organic matter. This can occur from motor vehicles, heaters, or cooking equipment that run on carbon-based fuels. It can also occur from exposure to methylene chloride. Carbon monoxide primarily causes adverse effects by combining with hemoglobin to form carboxyhemoglobin (HbCO) preventing the blood from carrying oxygen. Additionally, myoglobin and mitochondrial cytochrome oxidase are affected. Diagnosis is based on a HbCO level of more than 3% among nonsmokers and more than 10% among smokers.
Efforts to prevent poisoning include carbon monoxide detectors, proper venting of gas appliances, keeping chimneys clean, and keeping exhaust systems of vehicles in good repair. Treatment of poisoning generally consists of giving 100% oxygen along with supportive care. This should generally be carried out until symptoms are no longer present and the HbCO level is less than 10%. While hyperbaric oxygen therapy is used for severe poisonings, the benefit over standard oxygen delivery is unclear. The risk of death among those affected is between 1 and 30%.
Carbon monoxide poisoning is relatively common, resulting in more than 20,000 emergency room visits a year in the United States. It is the most common type of fatal poisoning in many countries. In the United States, non-fire related cases result in more than 400 deaths a year. Poisonings occur more often in the winter, particularly from the use of portable generators during power outages.The toxic effects of CO have been known since ancient history.
Explanation:
Answer:
(1) Carbon monoxide poisoning is caused when carbon monoxide is combined with haemoglobin.
(2) Hacmoglobin is said to have 250 times more affinity for carbon monoxide than that for the oxygen.
(3) Therefore, haemoglobin with carbon monoxide forms a stable compound, the carboxyhemoglobin.
(4) Due to the formation of carboxyhaemoglobin, the haemoglobin no longer carries oxygen to the cells and tissues. Tissues then suffer from oxygen starvation. This leads to asphyxiation and in extreme cases it leads to death.
(5) Carbon monoxide poisoning occurs in closed rooms with incompletely burning substances such as stove burners or furnaces and garages having running automobile engines.