Question

Write a note on wobble hypothesis ​

Answer 1

The wobble hypothesis states that the third position (3') of the codon on mRNA and the first position (5') of the anticodon on tRNA are bound less tightly than the other pair and therefore, offer unusual base combinations. This phenomenon give rise to: The multiple codes for a given amino acid

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Answer 2

The Wobble hypothesis proposes that normal base pairing can occur between nitrogen bases in positions 1 and 2 of the codon and the corresponding bases (3 and 2) in the anticodon. Actually, the base 1 in anticodon can form non-Watson-Crick base pairing with the third position of the codon.