Write a reaction acetylide react with alkyl halide
Answers
Answer:
nucleophile and can undergo nucleophilic substitution reactions (usually SN2) with 1o or 2o alkyl halides (Cl, Br or ...
Explanation:
Acetylide refers to chemical compounds with the chemical formulas MC≡CH and MC≡CM, where M is a metal.[1] The term is used loosely and can refer to substituted acetylides having the general structure RC≡CM (where R is an organic side chain). Acetylides are reagents in organic synthesis. The calcium acetylide commonly called calcium carbide is a major compound of commerce.
Acetylides of the type RC2M are widely used in alkynylations in organic chemistry. They are nucleophiles that add to a variety of electrophilic and unsaturated substrates. A classic application is the Favorskii reaction.
Illustrative is the sequence shown below, ethyl propiolate is deprotonated by n-butyllithium to give the corresponding acetylide. This acetylide adds to the carbonyl center of cyclopentanone. Hydrolytic workup liberate the alkynyl alcohol.