Question

Write a short note on Down's syndrome?

Answer 1

Down syndrome (or Down's syndrome) is a chromosomal disorder caused by an error in cell division that results in an extra 21st chromosome.

The condition leads to impairments in both cognitive ability and physical growth that range from mild to moderate developmental disabilities.

Through a series of screenings and tests, Down syndrome can be detected before and after a baby is born.

Answer 2

Dear Student,

In humans, there are total 46 chromosomes. Any deviation from this results in aneuploidy.

● Down syndrome -

• Down's syndrome is caused by non-dysjuction of chromosomes during meiosis.
• Karyotype of Downs syndrome is usually trisommy 21.

# Clinical features -

• mental retardation
• webbing of neck
• flat facies
• upward slant to eye
• congenital defects
• dwarfism
• simian course
• infertility
• abnormal ears
• Brushfield spots

# Diagnosis -

• Down's syndrome can be diagnosed prenatally by karto-typing.

Thanks dear. Hope this helps you...