write down major steps involved in the extrinsic blood clotting
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Extrinsic Blood Clotting
- Extrinsic pathway of clotting is a part of the coagulation cascade process during hemostasis.
- Extrinsic pathway or tissue factor pathway is the clotting process activated by a protein tissue factor, the tissue thromboplastin, which is extrinsic to the blood.
Explanation:
Major steps of extrinsic pathway :
- A traumatic injury to tissues surrounding a blood vessel
- The extravascular cells, extrinsic to the bloodstream, upon a traumatic injury, releases factor III or thromboplastin.
- This is then converted to factor VII, which in combination with factor III forms an enzyme complex.
- Enzyme complex activates factor X
- Factor X initiates the common pathway
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