Write note on Mean residence time.
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When I first began learning about pharmacokinetics, I was often confused by the mean residence time (MRT) parameter. I wasn’t really sure what it meant, how to interpret the value, and why it would ever be important. After many years of working with pharmacokinetic analysis, I still do not use MRT very often, but I now have a better appreciate of what it is telling me so that I can use it properly, if needed.
To discuss MRT, we need to change the conversation from the concentration of drug in the body at a given time to the residence time of individual molecules in the body. The idea behind calculating the mean residence time is that each molecule spends a different amount of time in the body, with some molecules lasting a very short amount of time and others lasting longer. You can plot the relative frequency of the residence time in the body, and it looks like a concentration-time curve.