write quantity of urea,uric acid, creatinine excreated per 24 hours
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Creatinine clearance measured without (CC) or with cimetidine (CCWC), which is almost the same as inuline clearance due to the blocking effect that cimetidine has on the proximal tubular secretion of creatinine, has proved to be significantly lower in the very old healthy people in comparison to that documented on the younger population[1,2]: CC: 43 mL/min per 1.73 m2 (aged) vs 144 mL/min per 1.73 m2 (young), (P = 0.01); CCWC: 50 mL/min per 1.73 m2 (aged) vs 112 mL/min per 1.73 m2 (young), (P = 0.01). The observed difference in the creatinine filtration between the studied age groups could be justified as a consequence of the decrease in the number of glomerular units secondary to their obliteration due to the glomeruloscrerosis which accompanies ageing[3-5]. Even though, the above mentioned creatinine renal filtration difference between the age groups, there is no significant difference regarding their serum creatinine value between them. This phenomenon can be explained as the decrease in the creatine levels due to the senile diminution in lean body mass (tissues from where creatinine comes)
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