Question

Write short answer on biosynthesis of nucleic acid.​

Answer 1

Answer:

Activity and Mechanism of Action

They inhibit nucleic acid synthesis by inhibiting thymidylate synthase. Thymidylate synthase methylates deoxyuracilmonophoshate (dUMP) into deoxythyminemonophosphate (dTMP). Fluoropyrimidines, such as fluorocytosine (5-FC) and 5-fluorouracil (5-FU), are synthetic structural analogs of the DNA nucleotide cytosine. 5-FC itself has no antifungal activity, and its fungistatic properties are dependent upon the conversion into 5-FU. The drug rapidly enters the fungal cell through specific transporters, such as cytosine permeases or pyrimidine transporters, before it is converted into 5-FU by the cytosine deaminase [11]. These are also included in the category of Antimetabolites.

Answer 2

Answer:

Explanation:They inhibit nucleic acid synthesis by inhibiting thymidylate synthase. Thymidylate synthase methylates deoxyuracilmonophoshate (dUMP) into deoxythyminemonophosphate (dTMP). Fluoropyrimidines, such as fluorocytosine (5-FC) and 5-fluorouracil (5-FU), are synthetic structural analogs of the DNA nucleotide cytosine. 5-FC itself has no antifungal activity, and its fungistatic properties are dependent upon the conversion into 5-FU. The drug rapidly enters the fungal cell through specific transporters, such as cytosine permeases or pyrimidine transporters, before it is converted into 5-FU by the cytosine deaminase [11]. These are also included in the category of Antimetabolites.