write Short note on the following
a)Lock and key Hypothesis (or Rigid-Template)
b)Induced-fit hypothesis
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The lock and key hypothesis states that the substrate fits perfectly into the enzyme, like a lock and a key would.
This is in contrast with the induced fit hypothesis, which states that both the substrate and the enzyme will deform a little to take on a shape that allows the enzyme to bind the substrate.
Since, the substrate binds to a specific enzyme, this hypothesis is meant for the substrate specific enzymes.
Induced Fit hypothesis is proposed mechanism of interaction between an enzyme and a substrate. It postulates that exposure of an enzyme to a substrate causes the active site of the enzyme to change shape in order to allow the enzyme and substrate to bind (see enzyme–substrate complex). This hypothesis is generally preferred to the lock-and-key mechanism.
This is in contrast with the induced fit hypothesis, which states that both the substrate and the enzyme will deform a little to take on a shape that allows the enzyme to bind the substrate.
Since, the substrate binds to a specific enzyme, this hypothesis is meant for the substrate specific enzymes.
Induced Fit hypothesis is proposed mechanism of interaction between an enzyme and a substrate. It postulates that exposure of an enzyme to a substrate causes the active site of the enzyme to change shape in order to allow the enzyme and substrate to bind (see enzyme–substrate complex). This hypothesis is generally preferred to the lock-and-key mechanism.
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