Chemistry, asked by sydawg6850, 1 year ago

Write short notes on Synthesis of benzofuran.

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Answered by itprajwalkhulbe
1

Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings. This colourless liquid is a component of coal tar. Benzofuran is the "parent" of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants.

Benzofurans can be prepared by various methods in the laboratory. Notable examples include:

O-alkylation of salicylaldehyde with chloroacetic acid followed by dehydration (cyclication) of the resulting ether and decarboxylation.[3]

Benzofuran.png

Perkin rearrangement, where a coumarin is reacted with a hydroxide:[4][5][6]

Perkin rearrangement

Diels–Alder reaction of nitro vinyl furans with various dienophiles:[7]

Diels–Alder reaction yielding a substituted benzofuran

Cycloisomerization of alkyne ortho-substituted phenols:[8]

Benzofurans via Cycloisomerization

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