Question

write the Acylation of amines​

Answer 1

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Aliphatic and aromatic primary and secondary amines undergo acylation reaction. These amines contain replaceable hydrogen atoms (positively polarised H) on the nitrogen atom. These hydrogen atoms are replaced by acyl groups such as acetyl group. On reaction of amines with acetyl chloride or acetic anhydride, acetyl derivative of amine is obtained. It is also called amide. Amide is less basic than the amine. Acylation is a nucleophilic substitution reaction. The reaction is carried out in presence of strong base like pyridine, which neutralizes the acid produced during the reaction. For example : in photo

Benzoyl chloride also gives similar reaction with amines.