Question

write the CIP rules for assingning the absolute configuration around an asymmetric carbon​

Answer 1

Answer:

Illustrated Glossary of Organic Chemistry - Absolute Configuration. Absolute configuration: The spatial position of atoms or groups (i.e, the configuration) around a stereocenter, as determined by the Cahn-Ingold-Prelog rules, and designated as R or S....

Answer 2

The CIP system is used to assign an R or S configuration to a stereocenter and an E or Z configuration to a double bond.

Explanation:

• The full form of CIP is Cahn–Ingold–Prelog.
• The main aim of the CIP system is to assign an R or S configuration to a stereocenter and an E or Z configuration to a double bond. This is done so that the configuration of the entire molecule can be specified uniquely.
• Given below are the steps for naming molecules using the CIP rule:

1. Identify the stereocenters and double bonds.
2. Assign priorities to the groups attached to each stereocenter or double-bonded atom.
3. Assigning R/S and E/Z configuration.

• Wraps the molecule with the fingers in the direction from the higher priority molecule to the lower priority molecule. If the thumb points in the direction of the lowest priority molecule then the enantiomer is R; otherwise, it is S.
• Now, we look at the placing of the two highest priority substituents with respect to the double bond. If both high priority substituents are on the same side of the double bond then the stereoisomer is assigned a Z otherwise E.