write the mechanism of muscle relaxation
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Mechanism of Muscle Relaxation :
- The muscles contract when acetylcholine binds to the acetylcholine receptors which are present on the sacrolemma.
- On destruction of acetylcholine from the membrane bound receptors, the contracted muscles will again relax.
- Destruction of acetylcholine is done by an enzyme called as acetylcholinesterase which breaks acetylcholine into acetic acid and choline.
- Due to the destruction of acetylcholine the muscles come back in relaxed state.
- During muscle contraction the sacroplasmic reticulum will release the calcium stored in the sacroplasm.
- For muscle relaxation the Ca2+ ions from the sacroplasm are taken back into the sacroplasmic reticulum by a protein called as calsequestrin.
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Muscle contraction occurs when the thin actin and thick myosin filaments slide past each other. It is generally assumed that this process is driven by cross-bridges which extend from the myosin filaments and cyclically interact with the actin filaments as ATP is hydrolysed. Current biochemical studies suggest that the myosin cross-bridge exists in two main conformations.
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