write the metabolism of functioning of heart
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In the absence of oxygen, the heart can also degrade glucose to lactate and certain amino acids to succinate through pathways coupled to substrate-level phosphorylation of ADP to ATP. A fundamental principle is that in heart muscle cells, as in any living cell, function and metabolism are inextricably linked.
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Metabolism in the Normal Heart
The remaining 5% comes mainly from glycolysis and to a lesser extent from the citric acid cycle (Krebs cycle). The heart uses ≈60% to 70% of generated ATP to fuel contraction and the remaining 30% to 40% for various ion pumps, especially the Ca2+-ATPase in the sarcoplasmic reticulum.
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