Question

write the synthesis of
Nicotene.​

Answer 1

Answer:

(S)-nicotine is the natural compound synthesized by the tobacco plants[3],[4]. Only a few examples of an enantioselective synthesis of (S)-Nicotine have been reported. The isomers are usually separated from a racemic preparation by recristallisation. A four-step synthesis of (S)-Nicotine is described here.

a - Hydroxyketone 3 is obtained by a halogen-lithium exchange of 3-bromopyridine 1 with n-BuLi followed by treatment with the lactone 2.

b - The oxidation of the compound 3 to the aldehyde is accomplished with the Swern method: (COCl)2, DMSO, NEt3.

c - The desired product 4' is obtained by the reaction of (pyridin-3'-yl)-4-oxobutanone 4 with 2,3,4,6-tetra-O-pivaloyl-b-D-galactopyranosylamine a.

d - Acidic hydrolysis of 4' affords optically pure (S)- nornicotine: 1M HCl /MeOH.

Explanation:

Answer 2

Explanation:

(S)-nicotine is the natural compound synthesized by the tobacco plants[3],[4]. Only a few examples of an enantioselective synthesis of (S)-Nicotine have been reported. The isomers are usually separated from a racemic preparation by recristallisation. A four-step synthesis of (S)-Nicotine is described here. I hope this is helpful for you and please follow me