wweight variation test as per I.P for capsules
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weight variation test, measurement of contents is done by estimation of contents based on weight. Pharmacists often use and misuse this WV test by doing this test on all dosage units. If it is used correctly, this WV test can be used to measure content uniformity (CU). There are some conditions in which the weight difference can determine the percentage difference in the API in the individual dosage units. Hence this WV test can be useful in the quality control of drug production.
Capsules:
1. 20 capsules were selected at random.
2. One capsule was weighed. The capsule was opened and the contents were removed as completely as possible. The emptied shells were weighed. The net weight of it’s contents was determined, that was by subtracting the weight of the shells from the weight of the intact capsule.
3. The procedure was repeated with other 19 capsules.
4. The average net weight was determined from the sum of the individual net weights.
5. The percentage deviation from the average net weight of each capsule was determined.
Capsules:
1. 20 capsules were selected at random.
2. One capsule was weighed. The capsule was opened and the contents were removed as completely as possible. The emptied shells were weighed. The net weight of it’s contents was determined, that was by subtracting the weight of the shells from the weight of the intact capsule.
3. The procedure was repeated with other 19 capsules.
4. The average net weight was determined from the sum of the individual net weights.
5. The percentage deviation from the average net weight of each capsule was determined.
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