Question

1. [Background] Cytosine arabinoside (araC) is an anti-pyrimidine antimetabolite. In clinical, it is mainly used for the treatment of malignant blood diseases, malignant lymphoma, lung cancer, and also can be used for viral keratitis, and epidemic blood membrane inflammation. DNA polymerase, which can catalyze the forming of 3',5'-phosphodiester bond by using dNTPs (dATP, dTTP, OCTP, dGTP) to produce a deoxypolynucleotide chain. 1) According to the background, cytosine arabinoside can inhibit the activity of DNA polymerase, which kind of inhibition do you think it belong to? (2 points) 2) Please describe how cytosine arabinoside work to inhibit the activity of DNA polymerase, how to reduce the inhibition effect. (4 points) 3) Please describe the kinetic features of the process that cytosine arabinoside can inhibit the activity of DNA polymerase. (4 points) NH NH Kinase но. HO OH OH OH HO HCI HO HCI OH OH​

Answer 1

Answer:

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