1. why do neutrophils normally simply pass through capillaries ? 2. how does this change when tissue is damaged and neutrophil need to leave the cap and migrate in to tissue ? 3. describe the mechanism of extravasation (getting out of the vasculature ). please describe in 200 word.
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1. neutrophils normally simply pass through capillaries because neutrophyll is a part of wbcs.
3. Extravasation can cause tissue damage in different ways:
i) the drug is absorbed by local cells in the tissue and binds to critical structures (e.g. DNA, microtubules), causing cell death. After the endocytolysis, surrounding cells can also die through the release of the drug from nearby dead cells.
ii)the drug that does not bind to cellular DNA may metabolize and be cleared, limiting the degree of tissue injury. This is, therefore, more easily neutralized
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Because neutrophyll is a part of white blood cells.
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