A dissolution test was conducted for paracetamol in a stimulated gastric fluid (SGF), which contains sodium chloride and hydrochloric acid and at pH 1.5 , Would you expect to see any difference in dissolution profile for paracetamol if the dissolution test was performed in simulated intestinal fluid (SIF) at pH 6.5 ? Explain your answer by giving the approximate % ionisation at pH 1.5 and pH 6.5
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