A homology models has been generated for a protein whose only primary structure is known. How will you predict whether this model is the correct 3D representation of the protein?
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Homology modeling, also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template").
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Protein structure predictions based on energy minimization methods are rooted in observations that native protein structures correspond to a system at thermodynamic equilibrium with a minimum free energy
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