Question

A patient is suffering from Parkinson's disease. Suggest the modern technique to treat this disease.

Answer 1

Thanks for the question!

It is definitely a very interesting question to solve and do some brainstorming.

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Modern techniques are used to lessen the effect of symptoms or give a symptomatic effect, but, there are no cure actually designed for people suffering with Parkinson's disease only treatments can bring about changes concerning Parkinson's disease. Most of the neurologists promote the use of Levodopa and Dopamine agonists, they can be used effectively to clear the symptoms. MOA-B Inhibitors can be also used when the patient is suffering from Parkinson's disease at at a early venture or time to suppress dyskinesias and promoting more of voluntary movements and to increase the facial expressions (by killing involuntary movements involved in it).

The use of Levodopa or known by IUPAC name L-3,4-dihydroxyphenlyalanine which have been primarily used for mediating and differentiating between the Development of matured neurons through neurotrophic factors. It has a clinical significance and a medical importance for the use in Parkinson's disease. They work through the mechanisms of crossing a border or line formed through endothelial cells formed in the capillary walls, collectively, the blood-brain barrier providing more travelling through systems rather than Dopamine which does not have that much ability to travel access to blood-brain barrier. This simply causes the conversion I to Dopamine after it has reached the vital organ (conversion done by dopaminergic neurons by the help of catalyst which is a Aromatic compound known as Aromatic L-amino acid decarboxylase or AAAD or tryptophan decarboxylase as it causes a feeling of euphoria). The production of Dopamine in the brain rules out the possibility of motor neuron related disorders and clears out symptoms effectively.

Dopamine agonists show similar effects and also contribute to cross over of blood-brain barrier and does production of Dopamine inside the neuro-gilal cells. They were first used to solve he problems of fluctuations produced through Levodopa and to clear the effects of dyskinesias again produced by Levodopa. They are administered from the media of injections and oral administration has been prohibited (subcutaneous layers are punctured and inserted throughout). Best example for a Dopamine would be Apomorphine which can also be used for private therapies or treatment for heroin addicts.

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Hope it helps and solves your query!!