Question

A phase i trial of tumor treating fields with and without concomitant temozolomide and bevacizumab in pediatric patients with high-grade glioma and ependymoma

Answer 1

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High-grade gliomas (HGG) comprise 8–12% of brain tumors in children and include anaplastic astrocytoma or glioblastoma multiforme (GBM) pathology. Ependymoma is the third most common pediatric brain tumor accounting for 5–10% of all diagnoses. Treatment for these tumors involves surgical resection, adjuvant radiation and chemotherapy. The prognosis for high-grade glioma and recurrent ependymoma is poor and new therapies must be investigated to improve clinical outcomes for these patient populations.