About age reversal therapy and it's application
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Human Age Reversal
We May Be There Already!
By Jasti prem sivesh
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prem sivesh speaking on December 8, 2016, at an age-reversal seminar in Fort Lauderdale, Florida.
We made medical history at the inaugural Revolution against Aging and Death (RAADfest) conference held in August 2016.
For the first time, scientific methods to help enable older people to grow biologically younger were revealed.
RAADfest was the largest gathering of radical longevity enthusiasts ever.
Of the age reversal research projects that need outside funding, we’ve identified what appear to be the proverbial “low-hanging fruit.” This means these treatments offer strong potential for reversing human aging right now!
Our immediate goal is to expeditiously develop these therapies to provide an additional 20-30 years of healthy longevity to older individuals.
The reason this extra time is so critical is that within the next 20-30 years science may gain total control over pathologic aging processes.
This article contains Power Point slides demonstrating that biological age reversal is already occurring in proof-of-concept studies.
Based on the data you are about to see, millions of human lives may be spared.
We need to confirm these findings in larger population groups. Continued demonstration of biological age reversal will likely move these treatments into routine medical protocols for people over age 60.
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The Power Point slide above describes age-reversal effects measured when dasatinib was administered to older mice.
There are five age-reversal projects that can be launched right now if funding becomes available.
What’s so tantalizing about these studies is that no new drug needs to be discovered to begin testing these therapies on older individuals.
The simplest human trial involves an FDA-approved drug called dasatinib that demonstrated profound age reversal effects in a mouse study published in 2015.
Just one dasatinib tablet taken for three consecutive weeks might induce systemic rejuvenating effects in people. There are several dasatinib doses we want to see tested along with other agents we think will work synergistically with this drug.
The cost of this drug is remarkably low since only three tablets might be needed to be taken every 5 or 10 years.
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The slide above shows five studies that offer strong potential to rapidly induce systemic age reversal.
Growth Differentiation Factor 11 (GDF11)
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Harvard scientists are reversing aging in old mice using Growth Differentiating Factor 11 (GDF11). (Science, Oct 21, 2015.)
GDF11 is a naturally occurring peptide that has the capacity to restore aging muscles, hearts, and brains in mice.
Researchers at Harvard (and other institutions) have shown it may induce significant age reversal effects.
GDF11 had never been tested in humans until a pioneering longevity enthusiast became patient zero on June 7, 2014.
About 20 volunteers are now self-experimenting and measuring biomarkers to determine GDF11’s effectiveness.
Power Point slides on pages 13 and 14 describe the rationale for using GDF11, its mechanisms of action, and the human age-reversal effects demonstrated so far.
Conclusion: The preliminary data from a cohort of humans self-experimenting with GDF11 indicate an urgent need for a controlled clinical trial to see if these age-reversal effects are reproducible among a larger group of individuals over age 55.