advancement in the research of rickets
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Answers
ANSWER—
IN SMALL —
Rickets has emerged as a public-health problem in Bangladesh during the past two decades, with up to 8% of children clinically affected in some areas. Insufficiency of dietary calcium is thought to be the underlying cause, and treatment with calcium (350–1,000 mg elemental calcium daily) is curative.
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IN MEDIUM —
Rickets has emerged as a public-health problem in Bangladesh during the past two decades, with up to 8% of children clinically affected in some areas. Insufficiency of dietary calcium is thought to be the underlying cause, and treatment with calcium (350–1,000 mg elemental calcium daily) is curative. Despite this apparently simple treatment, little is known about the most appropriate management of bone deformities of affected children, and further studies are needed to determine the details of dosing and duration of calcium therapy, the role of bracing, and specific indications for surgical intervention.
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IN LARGE —
Rickets has emerged as a public-health problem in Bangladesh during the past two decades, with up to 8% of children clinically affected in some areas. Insufficiency of dietary calcium is thought to be the underlying cause, and treatment with calcium (350–1,000 mg elemental calcium daily) is curative. Despite this apparently simple treatment, little is known about the most appropriate management of bone deformities of affected children, and further studies are needed to determine the details of dosing and duration of calcium therapy, the role of bracing, and specific indications for surgical intervention. Effective preventive measures that can feasibly reach entire communities are needed, and these may differ between various affected regions.
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IN LARGER —
Rickets has emerged as a public-health problem in Bangladesh during the past two decades, with up to 8% of children clinically affected in some areas. Insufficiency of dietary calcium is thought to be the underlying cause, and treatment with calcium (350–1,000 mg elemental calcium daily) is curative. Despite this apparently simple treatment, little is known about the most appropriate management of bone deformities of affected children, and further studies are needed to determine the details of dosing and duration of calcium therapy, the role of bracing, and specific indications for surgical intervention. Effective preventive measures that can feasibly reach entire communities are needed, and these may differ between various affected regions.
Rickets is a condition associated with bone-deformity due to inadequate mineralization in growing bones (1,2). While some cases relate to hereditary syndromes, renal disease, or use of medication, rickets in the world mostly stems from nutritional insufficiency (3). Nutritional rickets is prevalent throughout much of the developing world and is again being increasingly seen in more affluent countries (3). Rickets has become common in some parts of Bangladesh during the past two decades. Indeed, the lay press has lamented the pain, deformity, and disability due to rickets (4), and one recent report even claimed that there were 5,000,000 affected children in Bangladesh (5).
In an effort to review current knowledge about nutritional rickets and to prioritize ongoing research, 135 people gathered in Dhaka in January 2006 for an International Congress on Rickets. Fourteen clinician-scientists—as part of the Rickets Convergence Group—provided plenary presentations, and other delegates contributed to lively discussions. Arising from material presented at this congress, this article provides an overview of the history, epidemiology, clinical findings, treatment, and prevention of nutritional rickets from both global and Bangladeshi perspectives. In so doing, an agendum for future research is proposed.