Question

Advantages and disadvantages of low shear granulation

Answer 1

shear granulation is a shaping process for granulation that has been enhanced for application in the pharmaceutical industry. A binder liquid is fed to the powder particles in a closed container with blending tools and a chopper.

Advantage-

Granulation process requires less binder solution.

Granulation is achieved within a short time.

Disadvantage-

High-shear granulator produces less compressible granules when compared to low-shear granulator.

It has a narrow range of operating conditions.

Over wetting of the granules may lead to formation of large sized lumps.