Question

Amine that cant be prepared by Grabial Pthalimide synthesis is?

Answer 1

Gabriel phthalimide synthesis is used for the preparationof aliphatic primary amines. It involves nucleophilic substitution (SN2) of alkyl halides by the anion formed by thephthalimide.

Answer 2

Answer:

✔Aromatic amines cannot be prepared by Gabriel Phthalimide synthesis reaction because aryl halides do not undergo nucleophilic substitution with the anion formed by phthalimide.

✔It is used for the preparation of primary aliphatic amines.

✔Phthalimide on treatment with ethanolic potassium hydroxide forms potassium salt of phthalimide which on heating with alkyl halide followed by alkaline hydrolysis produces the corresponding primary amine.