are memory cells produced when a child is vaccinated against tuberculosis?
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Abstract
Tuberculosis (TB ) is a serious infectious disease caused by infection with Mycobacterium tuberculosis , and kills more people annually than any other single infectious agent. Although a vaccine is available, it is only moderately effective and an improved vaccine is urgently needed. The ability to develop a more effective vaccine has been thwarted by a lack of understanding of the mechanism of vaccine‐induced immune protection. Over recent decades, many novel TB vaccines have been developed and almost all have aimed to generate memory CD 4 T cells. In this review, we critically evaluate evidence in the literature that supports the contention that memory CD 4 T cells are the prime mediators of vaccine‐induced protection against TB . Because of the lack of robust evidence supporting memory CD 4 T cells in this role, the potential for B‐cell antibody and “trained” innate cells as alternative mediators of protective immunity is explored.
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Tiberculosis is a serious infectios disease caused by infection with mycobecterium tuberculosis, and kill more people annually than any other single infectious agent. Although a vaccine is available, it is moderately effective and an improved vaccine is urgently is needed,. The ability to develop a more effective vaccine has been thwarted by a lack of understanding of vaccine- inducd immune protection.