Avery, Macleod and McCarty - experiment
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All living organisms have genetic material in the form of D.N.A.
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(1) In 1944, Oswald T. Avery, Colin M. MacLeod and Maclyn McCarty proved that the DNA is a genetic material (transforming principle).
(2) They purified DNA. RNA. proteins (enzymes) and other materials from heat killed S-srain cells and mixed them with cells of R-strain bacteria separately to confirm which one could transform living R cells into S cells.
(3) Only DNA was able to transform harmless R-strain into virulent S-strain.
(4) They also demonstrated that proteases, RNases did not affect transformation. Thus it was proved that the transtorming Substance was neither a protein nor-RNA.
(5) When DNA was digested with DNase, there was no transformation.
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