biginelli reaction is the example of which matter
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biginelli reaction is the example
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This reaction was developed by Pietro Biginelli in 1891. The reaction can be catalyzed by Brønsted acids and/or by Lewis acids such as copper(II) trifluoroacetate hydrate[7] and boron trifluoride.[8] Several solid-phase protocols utilizing different linker combinations have been published.[9][10]
Dihydropyrimidinones, the products of the Biginelli reaction, are widely used in the pharmaceutical industry as calcium channel blockers,[11] antihypertensive agents, and alpha-1-a-antagonists.
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