Question

breif note on prions

Answer 1

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases in humans and many other animals. It is not known what causes the normal protein to misfold; the abnormal three-dimensional structure is suspected of conferring infectious properties.

Answer 2

NOTE ON PRIONS:-

Generally, infectious agents are either viroids, vi­ruses, prokaryotic cells (e.g., bacteria), or eukaryotic cells (e.g., certain protists). What these infectious agents have in common is that their identity is defined by the nucleic acid that each carries. Although there is still considerable debate on the matter, it now appears that there may be an exception to this rule.

Scrapie (a disease of goats and sheep) and a disease of the ner­vous system in humans called Creutzfeldt-Jakob dis­ease) appear to be caused by agents consisting only of protein; the agents of these diseases are called prions. The protein comprising a prion has a molecular weight between 50,000 and 100,000, corresponding to a parti­cle size that is 100 times smaller than the smallest vi­ruses.

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