Question

Can anyone explain me functioning of juxtamedullary nephron P.S I may ask some question in the comments section

Answer 1

Juxtamedullary nephrons, unlike those farther away from the renal medulla, have long nephron loops than extend deep into the medulla. They make the greatest contribution to the osmotic gradient of the medulla, and it’s this gradient that enables the kidneys to conserve water and secrete hypertonic urine. Without the juxtamedullary nephrons, our urine would have about the same osmotic concentration as our blood, we would lose a tremendous amount of water from the body every day through the urine, and we’d be insatiably thirsty all the time. The signs and symptoms of this would be essentially the same as for diabetes insipidus.