Question

Can anyone please explain me the effects of psilocybin on our body and nervous system?

Answer 1

Ingesting hallucinogenic drugs can cause users to see images, hear sounds, and feel sensations that seem real but do not exist. Their effects typically begin within 20 to 90 minutes of ingestion and can last as long as 12 hours. Experiences are often unpredictable and may vary with the amount ingested and the user’s personality, mood, expectations, and surroundings. The effects of hallucinogens like LSD can be described as drug-induced psychosis—distortion or disorganization of a person’s capacity to recognize reality, think rationally, or communicate with others. Users refer to LSD and other hallucinogenic experiences as “trips” and to acute adverse or unpleasant experiences as “bad trips.” On some trips, users experience sensations that are enjoyable and mentally stimulating and that produce a sense of heightened understanding. Bad trips, however, include terrifying thoughts and nightmarish feelings of anxiety and despair that include fears of losing control, insanity, or death.

Like LSD and psilocybin, DMT produces its effects through action at serotonin (5-HT) receptors in the brain (Strassman, 1996). Some research has suggested that DMT occurs naturally in the human brain in small quantities, leading to the hypothesis that release of endogenous DMT may be involved in reports of alien abductions, spontaneous mystical experiences, and near-death experiences, but this remains controversial (Barker, 2012).

Specific short-term effects of LSD, psilocybin, peyote, DMT, and ayahuasca include:

LSD

Increased blood pressure, heart rate, and body temperatureDizziness and sleeplessnessLoss of appetite, dry mouth,and sweatingNumbness, weakness, and tremorsImpulsiveness and rapid emotional shifts that can range from fear to euphoria, with transitions so rapid that the user may seem to experience several emotions simultaneously

Psilocybin

Feelings of relaxation (similar to effects of low doses of marijuana)Nervousness, paranoia, and panic reactionsIntrospective/spiritual experiencesMisidentification of poisonous mushrooms resembling psilocybin could lead to unintentional, potentially fatal poisoning

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