Question

Cause of failure of wide hybridization by chromosome imbalance and meiotic instability

Answer 1

Allelic Imbalance and Microsatellite Instability. Chromosomal instability is characterized by allelic losses and aneuploidy. ... This phenotype was linked to defects in the DNA mismatch repair genes MSH2 and MLH1 located on chromosomes 2 and 3. In HCC these chromosomal regions are not frequently affected by allelic losses.

Answer 2

Hola User

Allelic Imbalance and Microsatellite Instability. Chromosomal instability is characterized by allelic losses and aneuploidy. ... This phenotype was linked to defects in the DNA mismatch repair genes MSH2 and MLH1 located on chromosomes 2 and 3. In HCC these chromosomal regions are not frequently affected by allelic losses.