Cell membrane thicknesses of alpelisib drug
Answers
Answer:
PubChem CID:
56649450
Structure:
Alpelisib_small.png
Alpelisib_3D_Structure.png
Find Similar Structures
Chemical Safety:
Health Hazard
Laboratory Chemical Safety Summary (LCSS) Datasheet
Molecular Formula:
C19H22F3N5O2S
Synonyms:
alpelisib
1217486-61-7
BYL-719
BYL719
Alpelisib (BYL719)
More...
Molecular Weight:
441.5 g/mol
Dates:
Modify:
2019-12-08
Create:
2012-03-05
Description:
Alpelisib is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.
from NCI Thesaurus (NCIt)
(2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide is a proline derivative.
from ChEBI
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α [A179203], which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human cancers, leading to hyperactivation.