Biology, asked by sahirasrii6934, 1 year ago

Cell membrane thicknesses of alpelisib drug

Answers

Answered by Anonymous
3

Answer:

PubChem CID:

56649450

Structure:

Alpelisib_small.png

Alpelisib_3D_Structure.png

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Chemical Safety:

Health Hazard

Laboratory Chemical Safety Summary (LCSS) Datasheet

Molecular Formula:

C19H22F3N5O2S

Synonyms:

alpelisib

1217486-61-7

BYL-719

BYL719

Alpelisib (BYL719)

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Molecular Weight:

441.5 g/mol

Dates:

Modify:

2019-12-08

Create:

2012-03-05

Description:

Alpelisib is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.

from NCI Thesaurus (NCIt)

(2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide is a proline derivative.

from ChEBI

Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α [A179203], which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human cancers, leading to hyperactivation.

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