Question

Characterization of progressive motor deficits in mice transgenic for the human huntington's disease mutation

Answer 1

A transgenic mice that had the human huntington disease gene developed a neurological phenotype that was progressive in nature and had the motor symptoms which the disease geen carries.

There was no sort of overt behavorial phenotype until it was 8 weeks old, but there was a significant difficulty in doing different activites such as swimming, maintaining balance etc.