Question

Chronic myeloid leukemia (CML) is a genetic disorder associated with the Philadelphia chromosome. The Philadelphia chromosome is a mutation in chromosome 22. Part of chromosome 22 is exchanged with part of chromosome 9, bringing together two genes on chromosome 22 and causing a malignancy. What type of mutation occurs in the Philadelphia chromosome?
A.
duplication
B.
insertion
C.
inversion
D.
substitution
E.
translocation

Answer 1

Answer:

b

Explanation:

Answer 2

Translocation occurs in the Philadelphia chromosome.

• In replication, more than one set of the genetic sequence (nitrogen bases) is transcribed. This results in frameshift mutation if one or two bases are duρliςαted.

• In insertion, a new base is added in between existing bases. This causes frameshift mutation.

• During inversion, the gene sequence breaks and then is attached in the reverse order.

• In substitution, an existing purine or pyrimidine is exchanged with another purine or pyrimidine. Sickel cell anemia is caused due to substitution mutation.
• Translocation occurs when the genetic sequence of one chromosome gets tied to another chromosome.