Compare n contrast necrosis and apoptosis?
Answers
apoptosis is a form of cell death that is generally triggered by normal, healthy processes in the body, necrosis is cell death that is triggered by external factors or disease, such as trauma or infection. Apoptosis, which can also occur as a defense mechanism during healing processes, is almost always normal and beneficial to an organism, while necrosis is always abnormal and harmful. Though necrosis is being researched as a possible form of programmed cell death (that is, a sometimes natural process), it is considered an "unprogrammed" (unnatural) cell death process at this time. As a usually healthy form of a cell's life cycle, apoptosis rarely demands any form of medical treatment, but untreated necrosis can lead to serious injury or even death.
Comparison chart
Apoptosis versus Necrosis comparison chart
Apoptosis Necrosis
Introduction Apoptosis, or programmed cell death, is a form of cell death that is generally triggered by normal, healthy processes in the body. Necrosis is the premature death of cells and living tissue. Though necrosis is being researched as a possible form of programmed cell death, it is considered an "unprogrammed" cell death process at this time.
Natural Yes Caused by factors external to the cell or tissue, such as infection, toxins, or trauma.
Effects Usually beneficial. Only abnormal when cellular processes that keep the body in balance cause too many cell deaths or too few. Always detrimental
Process Membrane blebbing, shrinkage of cell, nuclear collapse (nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation), apoptopic body formation. Then, engulf by white blood cells. Membrane disruption, respiratory poisons and hypoxia which cause ATP depletion, metabolic collapse, cell swelling and rupture leading to inflammation.
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Symptoms Usually no noticeable symptoms related to the process. Inflammation, decreasing blood flow at affected site, tissue death (gangrene).
Causes Self-generated signals in a cell. Generally natural part of life, the continuation of the cellular cycle initiated by mitosis. Bacterial or fungal infections, denatured proteins that impede circulation, fungal and mycobacterial infections, pancreatitis, deposits of antigens and antibodies combined with fibrin.
Medical Treatment Very rarely needs treatment. Always requires medical treatment. Untreated necrosis is dangerous and can lead to dea