Question

Cytotoxicity of iron oxide nanoparticles

Answer 1

Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling
Stefaan JH Soenen, Uwe Himmelreich, Nele Nuytten, Marcel De Cuyper
Biomaterials 32 (1), 195-205, 2011
The in vitro labelling of cultured cells with iron oxide nanoparticles (NPs) is a frequent practice in biomedical research. To date, the potential cytotoxicity of these particles remains an issue of debate. In the present study, 4 different NP types (dextran-coated Endorem, carboxydextran-coated Resovist, lipid-coated magnetoliposomes (MLs) and citrate-coated very small iron oxide particles (VSOP)) are tested on a variety of cell types, being C17. 2 neural progenitor cells, PC12 rat pheochromocytoma cells and human blood outgrowth