Question

D acromegaly
7. Acetylcysteine is a specific antidote for
which of the following overdose-related
poisoning?
A Aspirin
B. Atropine
C. Phenacetin
D Acetaminophen​

Answer 1

Acetyl cysteine is the specific antidote for Acetaminophen (Paracetamol).

• It's is often seen that Paracetamol overdose results in its toxicity in various organs.

• The organs mainly involved are kidney and liver.

• Metabolism of paracetamol produces a metabolite named NAPQ1 (N-amino P-benzo quinoneimine 1) , which covalently links with proteins and cause necrosis of hepatic or renal parenchyma.

• So, acetyl-cysteine is added as an antidote.

• It produces Sulfhydryl Group (-SH), which causes proper metabolism of paracetamol.

• It also replenishes the glutathione stores of the liver and prevents cell necrosis.

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• The other substances used in Acetaminophen toxicity is Activated Charcoal to prevent absorption of the drug.

• Hemodialysis also has effective use.

$\star$ Hope It Helps.