Define tight junctions with diagrm.
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Tight junctions
- seal adjacent epithelial cells in a narrow band just beneath their apical surface.
- They consist of a network of claudins and other proteins.
Tight junctions perform two vital functions:
- They limit the passage of molecules and ions through the space between cells.
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In a tight junction, a series of integral protein molecules in the plasma membranes of adjacent cells fuse together, forming an impermeable junction that encircles the cell. Tight junctions help prevent molecules from passing through the extracellular space between adjacent cells.
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