Question

Describe the film theory for absorption of drugs. What are its assumptions?

Answer 1

The rate and extent of drug loss from the human oral cavity can be measured using several different methods. These include the buccal absorption test (Beckett and Triggs, 1967), disc methods (Kaaber, 1974; Schurr and Ziegler, 1983; Pimlott and Addy, 1985) and perfusion cells (Barsuhn et al., 1988, Rathbone, 1990). These methods have provided information on the mechanisms by which drugs are transported across oral cavity membranes and suggest that passive diffusion (Beckett and Triggs, 1967; Beckett and Moffat, 1968, 1969a,b) or carrier-mediated transport systems (Manning and Evered, 1976; Sadoogh-Abasian and Evered, 1979; Evered et al., 1980; Evered and Mallett, 1983