Describe the mechanism of biotransformation with phase reaction.
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Biotransformation is the chemical modification made by an organism on a chemical compound. If this modification ends in mineral compounds like CO₂, NH₄⁺, or H₂O, the biotransformation is called mineralisation.
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▶Biotransformation is the metabolic process by which the liver alters or modifies substances entering the body, such as drugs.
Metabolism may be inhibited or enhanced resulting in unexpected drug interactions, which can produce serious side effects or be life-threatening.
▶It appears that the metabolism of most foreign compounds occurs in two phases. The first phase involves oxidations, reductions or hydrolyses or a combination of any of these three, and for convenience these may be termed “phase I reactions”; the second phase (“phase II reactions”) consists of synthesis, mainly conjugations such as glucuronide, ethereal sulphate, thiocyanate, and hippuric acid formation
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