Question

Describe the Wobble hypothesis.

Answer 1

Here is your answer buddy,

The Wobble hypothesis proposes that normal base pairing can occur between nitrogen bases in positions 1 and 2 of the codon and the corresponding bases (3 and 2) in the anticodon. Actually, the base 1 in anticodon can form non-Watson-Crick base pairing with the third position of the codon.

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Answer 2

Wobble hypothesis:

• Wobble Hypothesis was elucidated by "Francis Crick", states that the $3^{rd}$ base in an "mRNA codon" undergoes "non-Watson Crick base pairing" with the first base found in the tRNA anticodon.
• First two bases in mRNA codon forms Hydrogen bonds with the corresponding bases on tRNA anticodon in conventional "Watson-crick manner", in which they only form pairs with their complementary bases.

• However, the formation of Hydrogen bonds between the $3^{rd}$ base and the $1^{st}$ base, generally occurs in the Watson-Crick manner.